To explore the protective effect of bilobalide on pheochromocytoma cell injury induced by oxygen-glucose deprivation/reperfusion in vitro. simulate ischemia-reperfusion condition, was The cells were divided into control, and deprivation/ reperfusion+bilobalide groups. viability, proliferative capacity, malondialdehyde level, superoxide dismutase apoptosis, Wnt1 protein level nuclear beta-cateni...

organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. the pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. in this review, we discuss basic mechanisms...

background: it has been reported that the chronic oral administration of garlic homogenate protected the rat heart from in vitro ischemic reperfusion injury. however, the biological effects of garlic juice on the heart are expected to be different from oral administration of it. objective: the present study was designed to investigate the effect of garlic juice on the isolated rat heart in isch...

Background:Troxerutin has antioxidant and anti-inflammatory properties and in this study, its antioxidant effect on the reduction of oxidative stress induced by ischemia-reperfusion sciatic nerve injury was investigated. Methods:In this study, 64 male rats were randomly divided into 8 groups as follows: 1- IR2: ischemia (3 hours) and reperfusion (2 days), 2- T...

Organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. The pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. Protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. In this review, we discuss basic mechan...

We investigated the metabolism of mouse isolated heart under influence tricarbonyldichlorothenium (II)- dimer (CORM-2 and 2,3-4,5-bis-O-isopropylidene-βD-fructopyranose sulfamate (topiramate) as potential blockers aquaporine channel (AQP3) cardiac myocytes. The results were compared with those obtained from group receiving anti-AQP3 monoclonal antibodies. A decrease in coronary flow was found d...

Objective: Ischemia-reperfusion (I-R) injury is defined as the paradoxical exacerbation of cellular dysfunction and death following restoration blood flow to ischemic tissues. In our study, it was aimed examine potential DNA effects liver IR with an experimental animal model. Material Methods: modeling done seven male New Zealand rabbits. Blood samples were taken before model, 30 minutes after ...

objective: it is generally agreed that most of the phenomena observed during brain ischemia and reperfusion can be explained by the damage to membrane structure. oxidative stress is resulted in an imbalance between high consumption of oxygen and low levels of endogenous antioxidants. it is known that gallic acid (ga) is a strong antioxidant. the present study was carried out to evaluate the eff...

ischemia-reperfusion injury is a possible cause of testicular damage and infertility after testicular torsion and detorsion. the purpose of this study was to evaluate the effect of ghrelin on testicular ischemia-reperfusion damage. a total of 30 adult male rats were selected for the study and divided randomly into 3 groups, each containing 10 rats. animals in the testicular torsion and ghrelin ...

ischemia-reperfusion injury is the tissue damage happened when blood supply returns to the tissue after a period of ischemia or shortage of oxygen. this brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. the aim of this study is investigating the effect of hydroalcoholic extract of  cyperus rotundus l. on the expression of the bcl-x1 an...